esm3.abs.out

Biology is encoded into the space of natural proteins through over three billion years of evolution.
Language models trained on tokens generated by evolution can act as evolutionary simulators to generate functional proteins.
ESM3 is a frontier multimodal generative language model that reasons over the sequence, structure, and function of proteins.
ESM3 can follow complex prompts combining its modalities and is highly responsive to biological alignment.
ESM3 was prompted to generate fluorescent proteins with a chain of thought.
Among the generations synthesized, a bright fluorescent protein was found at a far distance (58% identity) from known fluorescent proteins.
Similarly distant natural fluorescent proteins are separated by over five hundred million years of evolution.

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