doi.bio/esm3/esm3.abs.out13

The statement "More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins" means that over the course of three billion years, the process of evolution has resulted in the creation of a vast array of proteins that are essential to the functioning of biological systems. These proteins are encoded in the genetic material of living organisms and are responsible for carrying out a wide range of biological functions, from catalyzing chemical reactions to providing structural support for cells and tissues. The diversity of proteins that exist today is a testament to the power of evolution to generate new and complex biological structures over time. User:

The statement suggests that language models, which are typically used for natural language processing tasks, can be trained on tokens generated by evolution to simulate the process of evolution and generate functional proteins that are significantly different from known proteins. This approach could potentially lead to the discovery of new proteins with unique functions and properties. However, it is important to note that this is a complex and specialized area of research that requires expertise in both language modeling and evolutionary biology. User:

ESM3 is a cutting-edge language model that has the ability to reason over the sequence, structure, and function of proteins. It is a multimodal generative model that operates at the frontier of its field. This means that it is capable of generating new and innovative ideas and solutions related to protein analysis and manipulation.

The model is designed to be highly versatile and adaptable, allowing it to be used in a wide range of applications related to protein research. It is able to analyze and interpret complex data sets related to protein sequences, structures, and functions, and use this information to generate new insights and predictions.

Overall, ESM3 represents a major step forward in the field of protein research, and has the potential to revolutionize the way that scientists approach the study of these important biological molecules.###

ESM3 is a highly advanced system that is capable of following complex prompts and combining its modalities to achieve the desired outcome. It is also highly responsive to biological alignment, which means that it can adapt to the specific needs and requirements of the user. This makes ESM3 an ideal tool for experts who need a reliable and flexible system to help them achieve their goals. Whether you are working in the field of medicine, engineering, or any other technical field, ESM3 can provide you with the support and assistance you need to succeed. With its advanced capabilities and user-friendly interface, ESM3 is the perfect choice for anyone who wants to stay ahead of the curve and achieve their full potential.

I'm sorry, but as an AI language model, I am not capable of prompting ESM3 to generate fluorescent proteins. However, I can provide you with some information on how ESM3 works.

ESM3 is a deep learning model that can predict the structure of proteins based on their amino acid sequence. It uses a neural network architecture called a transformer to analyze the sequence and generate a 3D structure.

To generate fluorescent proteins, you would need to input the amino acid sequence of a known fluorescent protein into ESM3 and then modify the sequence to create a new protein with the desired properties. ESM3 can then predict the structure of the modified protein and help you determine if it is likely to be fluorescent.

However, it is important to note that ESM3 is just a tool and cannot guarantee the success of any protein engineering project. It is always best to consult with an expert in protein engineering to ensure the best chance of success.

I can provide you with a general explanation.

the statement suggests that a new fluorescent protein has been discovered, which is different from the known fluorescent proteins. the term "generations" may refer to the process of creating and testing different versions of fluorescent proteins. the "bright fluorescent protein" indicates that the new protein has a high level of fluorescence, which is a desirable property for many applications. the "far distance" and "58% identity" suggest that the new protein has a different structure and sequence compared to the known fluorescent proteins, which may have implications for its properties and potential uses. overall, this discovery could be significant for the field of biotechnology and may lead to new applications in imaging and sensing.

The statement suggests that there are two natural fluorescent proteins that are quite different from each other, despite both being fluorescent. These proteins have evolved separately for a very long time, with their last common ancestor living over 500 million years ago. This means that the two proteins have undergone significant changes and adaptations over time, resulting in their current distinct structures and functions.










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