Yousuf A Khan
Overview
Yousuf Khan is a Pakistani graduate student at Stanford University, where he is both a Knight-Hennessy Scholar and an NSF fellow. Khan studies translational recoding in the laboratory of Dr. Axel Brunger. He is also interested in applying techniques and tools from biophysics to study basic phenomena.
Education
Khan received his B.Sc. in Cellular Biology and Genetics from the University of Maryland, College Park, where he worked with Dr. Jon Dinman and discovered his love of translational reprogramming. He then went on to earn a master's degree as a Churchill Scholar from the University of Cambridge. He is currently pursuing a PhD in molecular and cellular physiology and a master's degree in biomedical informatics at the Stanford School of Medicine.
Research
Khan's research interests include biophysical phenomena such as ribosomal frameshifting and AAA+ ATPase function at the protein and RNA level. He has developed a bioinformatic program for detecting frameshift signals in humans and his work on frameshifting has been published in several journals, including Molecular Cell and Nature's Leukemia.
Awards and Honours
- Knight-Hennessy Scholar
- NSF fellow
- Barry Goldwater Fellow
- National Science Foundation Fellow
- Howard Hughes Medical Institute undergraduate Fellow
- Winston Churchill Scholar
Yousuf A Khan
Early Life and Education
Yousuf A Khan is a Pakistani PhD candidate at Stanford University in the Department of Molecular and Cellular Physiology. He is both a Knight-Hennessy Scholar and an NSF fellow. Khan completed his B.Sc. in Cellular Biology and Genetics from the University of Maryland, College Park, where he worked with Dr. Jon Dinman and discovered his love of translational reprogramming.
Research
Khan's research interests include applying techniques and tools from biophysics to study basic phenomena. He has developed a bioinformatic program for detecting frameshift signals in humans and has studied the role of recoding in viral genomes and whether human messages also undergo recoding. He has also worked on the following projects:
- Western Blot Analysis
- ROS regulate differentiation of visceralizing Leishmania species into the virulent amastigote form
- Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon
- Lack of evidence for ribosomal frameshifting in ATP7B mRNA decoding
- Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia
- Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity
Publications
- The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
- A programmed ribosomal frameshifting defect potentiates the transforming activity of the JAK2-V617F mutation
- Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene
- Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity
- Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis -Acting RNA Elements
- The JAK‐STAT pathway is regulated by miRNA mediated Ribosomal Frameshifting
Other Interests
Outside of his academic pursuits, Khan served as the president of the Pakistani Student Association and played on the school tennis team during his undergraduate studies. He is also involved in a program that helps students develop leadership skills and interact with politicians as part of his Knight-Hennessy Scholarship.
Yousuf A Khan
Early Life and Education
Yousuf A Khan is a PhD student at Stanford University, where he is a Knight-Hennessy Scholar and an NSF fellow. He received his B.Sc. in Cellular Biology and Genetics from the University of Maryland, College Park, where he worked with Dr. Jon Dinman and first became interested in translational reprogramming.
Research
Khan's research interests include biophysics, bioinformatics, and molecular biology. He has developed a bioinformatic program for detecting frameshift signals in humans, which he worked on during his master's degree as a Churchill Scholar at the University of Cambridge. He currently studies translational recoding in the laboratory of Dr. Axel Brunger.
Publications
- Evidence for a novel overlapping coding sequence in POLG initiated at a CUG start codon
- Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity
- Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements
- The JAK‐STAT pathway is regulated by miRNA-mediated Ribosomal Frameshifting
- The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
- Abstract 3034: A programmed ribosomal frameshifting defect potentiates the transforming activity of the JAK2-V617F mutation
- Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene
- Contesting the evidence for -1 frameshifting in immune-functioning C-C chemokine receptor 5 (CCR5) - the HIV-1 co-receptor
- covLLM: Large Language Models for COVID-19 Biomedical Literature
Advice for Students
Based on his own experience, Khan advises graduate students to consider the interpersonal relationships with potential lab mates when choosing a lab, as he has found that being happy where you work is important for success.
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